Researchers' Proposals

Regional and time-related variability of chromosomal aneuploidies in human sperm: Aneuploidy rate of human sperm is in the range of 6.5- - 100 %. An elevation in the winter months was reported in response to exposure to polluted air originating in the heavy use of coal as heating fuel. These results are based on studying frozen samples from different donors in the two compared periods. We also have studied sperm aneuploidy rate variability using FISH, and now propose to examine the potential short and long-term variability in the frequency of sperm aneupoidies in multiple semen samples from the same men both from Hungary and the collaborating EU region. Cohorts would be matched for common semen parameters, providing so far unparalleled data for the role of environmental toxicity in spermatogenesis, contributing also to important public health issues in both countries.